PINK1 phosphorylates ubiquitin predominantly in astrocytes

Loss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved...

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Detalhes bibliográficos
Publicado no:NPJ Parkinsons Dis
Main Authors: Barodia, Sandeep K., McMeekin, Laura J., Creed, Rose B., Quinones, Elijah K., Cowell, Rita M., Goldberg, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906478/
https://ncbi.nlm.nih.gov/pubmed/31840043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-019-0101-9
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