PINK1 phosphorylates ubiquitin predominantly in astrocytes

Loss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved...

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Bibliografski detalji
Izdano u:NPJ Parkinsons Dis
Glavni autori: Barodia, Sandeep K., McMeekin, Laura J., Creed, Rose B., Quinones, Elijah K., Cowell, Rita M., Goldberg, Matthew S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Brief Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906478/
https://ncbi.nlm.nih.gov/pubmed/31840043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-019-0101-9
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