PINK1 phosphorylates ubiquitin predominantly in astrocytes

Loss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved...

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Bibliografiske detaljer
Udgivet i:NPJ Parkinsons Dis
Main Authors: Barodia, Sandeep K., McMeekin, Laura J., Creed, Rose B., Quinones, Elijah K., Cowell, Rita M., Goldberg, Matthew S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Brief Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906478/
https://ncbi.nlm.nih.gov/pubmed/31840043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-019-0101-9
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