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Allosteric modulators restore orthosteric agonist binding to mutated CB(1) receptors
OBJECTIVES: To determine if diminished orthosteric agonist binding due to mutations in extracellular loops 1 or 2 of the cannabinoid receptor 1 (CB(1)) can be overcome by an allosteric modulator and restore agonist binding. METHODS: Binding assays were performed using a range of concentrations of or...
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| Udgivet i: | J Pharm Pharmacol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6906232/ https://ncbi.nlm.nih.gov/pubmed/31722122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.13193 |
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