Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

RNA replicons are a promising platform technology for vaccines. To evaluate the potential of lipid nanoparticle-formulated replicons for delivery of HIV immunogens, we designed and tested an alphavirus replicon expressing a self-assembling protein nanoparticle immunogen, the glycoprotein 120 (gp120)...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Melo, Mariane, Porter, Ely, Zhang, Yuan, Silva, Murillo, Li, Na, Dobosh, Brian, Liguori, Alessia, Skog, Pat, Landais, Elise, Menis, Sergey, Sok, Devin, Nemazee, David, Schief, William R., Weiss, Ron, Irvine, Darrell J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904793/
https://ncbi.nlm.nih.gov/pubmed/31515132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.08.007
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