Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

Following immunization, high-affinity antibody responses develop within germinal centers (GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and undergo somatic hypermutation. Antigen availability within GCs is important, as B cells must acquire and present ant...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:NPJ Vaccines
Prif Awduron: Martin, Jacob T., Cottrell, Christopher A., Antanasijevic, Aleksandar, Carnathan, Diane G., Cossette, Benjamin J., Enemuo, Chiamaka A., Gebru, Etse H., Choe, Yury, Viviano, Federico, Fischinger, Stephanie, Tokatlian, Talar, Cirelli, Kimberly M., Ueda, George, Copps, Jeffrey, Schiffner, Torben, Menis, Sergey, Alter, Galit, Schief, William R., Crotty, Shane, King, Neil P., Baker, David, Silvestri, Guido, Ward, Andrew B., Irvine, Darrell J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406516/
https://ncbi.nlm.nih.gov/pubmed/32802411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-020-00223-1
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