Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

Conventional immunization strategies will likely be insufficient for the development of a broadly neutralizing antibody (bnAb) vaccine to HIV or other difficult pathogens due to the immunological hurdles posed, including B cell immunodominance and germinal center (GC) quantity and quality. We found...

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Veröffentlicht in:Cell
Hauptverfasser: Cirelli, Kimberly M., Carnathan, Diane G., Nogal, Bartek, Martin, Jacob T., Rodriguez, Oscar L., Upadhyay, Amit A., Enemuo, Chiamaka A., Gebru, Etse H., Choe, Yury, Viviano, Federico, Nakao, Catherine, Pauthner, Matthias G., Reiss, Samantha, Cottrell, Christopher A., Smith, Melissa L., Bastidas, Raiza, Gibson, William, Wolabaugh, Amber N., Melo, Mariane B., Cosette, Benjamin, Kumar, Venkatesh, Patel, Nirav B., Tokatlian, Talar, Menis, Sergey, Kulp, Daniel W., Burton, Dennis R., Murrell, Ben, Schief, William R., Bosinger, Steven E., Ward, Andrew B., Watson, Corey T., Silvestri, Guido, Irvine, Darrell J., Crotty, Shane
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619430/
https://ncbi.nlm.nih.gov/pubmed/31080066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.012
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