In vitro evolution of enhanced RNA replicons for immunotherapy

Self-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we developed an in vitro evolution strategy and identi...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Li, Yingzhong, Teague, Brian, Zhang, Yuan, Su, Zhijun, Porter, Ely, Dobosh, Brian, Wagner, Tyler, Irvine, Darrell J., Weiss, Ron
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502795/
https://ncbi.nlm.nih.gov/pubmed/31061426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43422-0
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