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In vitro evolution of enhanced RNA replicons for immunotherapy

Self-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we developed an in vitro evolution strategy and identi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Li, Yingzhong, Teague, Brian, Zhang, Yuan, Su, Zhijun, Porter, Ely, Dobosh, Brian, Wagner, Tyler, Irvine, Darrell J., Weiss, Ron
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502795/
https://ncbi.nlm.nih.gov/pubmed/31061426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43422-0
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