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In vitro evolution of enhanced RNA replicons for immunotherapy
Self-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we developed an in vitro evolution strategy and identi...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6502795/ https://ncbi.nlm.nih.gov/pubmed/31061426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43422-0 |
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