Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer

Emerging evidence suggests that dysregulation of oncogenic pathways requires precise tuning in order for cancer to develop. To test this, we examined the overlap between cis-acting elements of the hypoxia-inducible factor (HIF) pathway and cancer-susceptibility polymorphisms as defined in genome-wid...

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Udgivet i:Sci Rep
Main Authors: Schmid, Virginia, Lafleur, Veronique N., Lombardi, Olivia, Li, Ran, Salama, Rafik, Colli, Leandro, Choudhry, Hani, Chanock, Stephen, Ratcliffe, Peter J., Mole, David R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904466/
https://ncbi.nlm.nih.gov/pubmed/31822727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55098-7
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