Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized in response to hypoxia and form heterodimers with HIF‐1β to activate a broad range of transcriptional responses. H...

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Détails bibliographiques
Publié dans:EMBO Rep
Auteurs principaux: Smythies, James A, Sun, Min, Masson, Norma, Salama, Rafik, Simpson, Peter D, Murray, Elizabeth, Neumann, Viviana, Cockman, Matthew E, Choudhry, Hani, Ratcliffe, Peter J, Mole, David R
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322389/
https://ncbi.nlm.nih.gov/pubmed/30429208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846401
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