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Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6

Histone deacetylase 6 (HDAC6) is emerging as a target for inhibition in therapeutic strategies aimed at treating cancer, neurodegenerative disease, and other disorders. Among the metal-dependent HDAC isozymes, HDAC6 is unique in that it contains two catalytic domains, CD1 and CD2. CD2 is a tubulin d...

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書誌詳細
出版年:Biochemistry
主要な著者: Osko, Jeremy D., Christianson, David W.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904440/
https://ncbi.nlm.nih.gov/pubmed/31755702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00934
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