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Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
Histone deacetylase 6 (HDAC6) is a critical target for drug design due to its role in oncogenic transformation and cancer metastasis, and is unique among all histone deacetylases in that it contains tandem catalytic domains designated CD1 and CD2. We now report the crystal structures of CD2 from Hom...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4990478/ https://ncbi.nlm.nih.gov/pubmed/27454933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2134 |
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