Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs

Oct4 is widely considered the most important among the four Yamanaka reprogramming factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for reprogramming mouse somatic cells to induced pluripotent stem cells (iPSCs). Simultaneous induction of Sox2 and cMyc in fibroblast...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Velychko, Sergiy, Adachi, Kenjiro, Kim, Kee-Pyo, Hou, Yanlin, MacCarthy, Caitlin M., Wu, Guangming, Schöler, Hans R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900749/
https://ncbi.nlm.nih.gov/pubmed/31708402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.10.002
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