Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs

Oct4 is widely considered the most important among the four Yamanaka reprogramming factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for reprogramming mouse somatic cells to induced pluripotent stem cells (iPSCs). Simultaneous induction of Sox2 and cMyc in fibroblast...

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發表在:Cell Stem Cell
Main Authors: Velychko, Sergiy, Adachi, Kenjiro, Kim, Kee-Pyo, Hou, Yanlin, MacCarthy, Caitlin M., Wu, Guangming, Schöler, Hans R.
格式: Artigo
語言:Inglês
出版: Cell Press 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900749/
https://ncbi.nlm.nih.gov/pubmed/31708402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.10.002
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