Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs

Oct4 is widely considered the most important among the four Yamanaka reprogramming factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for reprogramming mouse somatic cells to induced pluripotent stem cells (iPSCs). Simultaneous induction of Sox2 and cMyc in fibroblast...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Velychko, Sergiy, Adachi, Kenjiro, Kim, Kee-Pyo, Hou, Yanlin, MacCarthy, Caitlin M., Wu, Guangming, Schöler, Hans R.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900749/
https://ncbi.nlm.nih.gov/pubmed/31708402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.10.002
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