Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

The differential scanning fluorimetry (DSF) screening of 5.692 fragments in combination with benzenesulfonamide (BSA) against bovine carbonic anhydrase (bCA) delivered >100 hits that either caused, on their own, a significant thermal shift (ΔT(m), °C) in the protein melting temperature or signifi...

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Bibliographische Detailangaben
Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Krasavin, Mikhail, Kalinin, Stanislav, Zozulya, Sergey, Gryniukova, Anastasiia, Borysko, Petro, Angeli, Andrea, Supuran, Claudiu T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896451/
https://ncbi.nlm.nih.gov/pubmed/31797704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1698562
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