Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida(®)) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms

The non-nucleoside reverse transcriptase inhibitor VM1500A is approved for the treatment of HIV/AIDS in its N-acyl sulphonamide prodrug form elsulfavirine (Elpida(®)). Biochemical profiling against twelve human carbonic anhydrase (CA, EC 4.2.1.1) isoforms showed that while elsulfavirine was a weak i...

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Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Supuran, Claudiu T., Nocentini, Alessio, Yakubova, Elena, Savchuk, Nikolay, Kalinin, Stanislav, Krasavin, Mikhail
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143618/
https://ncbi.nlm.nih.gov/pubmed/34000969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1927007
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