Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII

[Image: see text] A substantial improvement of potency and selectivity of imidazoline-based inhibitors of hCA VII (a promising target for the treatment of seizures and neuropathic pain) was achieved by simply switching the position of the benzenesulfonamide moiety from N(1) (as in the earlier report...

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Publicado en:ACS Med Chem Lett
Autores principales: Kalinin, Stanislav, Kopylov, Stanislav, Tuccinardi, Tiziano, Sapegin, Alexander, Dar’in, Dmitry, Angeli, Andrea, Supuran, Claudiu T., Krasavin, Mikhail
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642015/
https://ncbi.nlm.nih.gov/pubmed/29057059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00300
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