Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII

[Image: see text] A substantial improvement of potency and selectivity of imidazoline-based inhibitors of hCA VII (a promising target for the treatment of seizures and neuropathic pain) was achieved by simply switching the position of the benzenesulfonamide moiety from N(1) (as in the earlier report...

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Publicat a:ACS Med Chem Lett
Autors principals: Kalinin, Stanislav, Kopylov, Stanislav, Tuccinardi, Tiziano, Sapegin, Alexander, Dar’in, Dmitry, Angeli, Andrea, Supuran, Claudiu T., Krasavin, Mikhail
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642015/
https://ncbi.nlm.nih.gov/pubmed/29057059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00300
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