Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII

[Image: see text] A substantial improvement of potency and selectivity of imidazoline-based inhibitors of hCA VII (a promising target for the treatment of seizures and neuropathic pain) was achieved by simply switching the position of the benzenesulfonamide moiety from N(1) (as in the earlier report...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kalinin, Stanislav, Kopylov, Stanislav, Tuccinardi, Tiziano, Sapegin, Alexander, Dar’in, Dmitry, Angeli, Andrea, Supuran, Claudiu T., Krasavin, Mikhail
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642015/
https://ncbi.nlm.nih.gov/pubmed/29057059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00300
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