A highly soluble Sleeping Beauty transposase improves control of gene insertion

The Sleeping Beauty (SB) transposon system is an efficient non-viral gene transfer tool in mammalian cells but its broad use has been hampered by uncontrolled transposase gene activity from DNA vectors, posing a risk for genome instability, and by the inability to use transposase protein directly. H...

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Bibliografiske detaljer
Udgivet i:Nat Biotechnol
Main Authors: Querques, Irma, Mades, Andreas, Zuliani, Cecilia, Miskey, Csaba, Alb, Miriam, Grueso, Esther, Machwirth, Markus, Rausch, Tobias, Einsele, Hermann, Ivics, Zoltán, Hudecek, Michael, Barabas, Orsolya
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894935/
https://ncbi.nlm.nih.gov/pubmed/31685959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0291-z
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