Structural Determinants of Sleeping Beauty Transposase Activity

Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be...

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Publicado en:Mol Ther
Autores principales: Abrusán, György, Yant, Stephen R, Szilágyi, András, Marsh, Joseph A, Mátés, Lajos, Izsvák, Zsuzsanna, Barabás, Orsolya, Ivics, Zoltán
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010145/
https://ncbi.nlm.nih.gov/pubmed/27401040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.110
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