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Structural Determinants of Sleeping Beauty Transposase Activity

Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Abrusán, György, Yant, Stephen R, Szilágyi, András, Marsh, Joseph A, Mátés, Lajos, Izsvák, Zsuzsanna, Barabás, Orsolya, Ivics, Zoltán
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010145/
https://ncbi.nlm.nih.gov/pubmed/27401040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.110
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