Structural Determinants of Sleeping Beauty Transposase Activity

Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Ther
Main Authors: Abrusán, György, Yant, Stephen R, Szilágyi, András, Marsh, Joseph A, Mátés, Lajos, Izsvák, Zsuzsanna, Barabás, Orsolya, Ivics, Zoltán
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010145/
https://ncbi.nlm.nih.gov/pubmed/27401040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.110
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