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Retargeting Sleeping Beauty Transposon Insertions by Engineered Zinc Finger DNA-binding Domains
The Sleeping Beauty (SB) transposon is a nonviral, integrating vector system with proven efficacy in preclinical animal models, and thus holds promise for future clinical applications. However, SB has a close-to-random insertion profile that could lead to genotoxic effects, thereby presenting a pote...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464645/ https://ncbi.nlm.nih.gov/pubmed/22776959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.126 |
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