Retargeting Sleeping Beauty Transposon Insertions by Engineered Zinc Finger DNA-binding Domains

The Sleeping Beauty (SB) transposon is a nonviral, integrating vector system with proven efficacy in preclinical animal models, and thus holds promise for future clinical applications. However, SB has a close-to-random insertion profile that could lead to genotoxic effects, thereby presenting a pote...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Voigt, Katrin, Gogol-Döring, Andreas, Miskey, Csaba, Chen, Wei, Cathomen, Toni, Izsvák, Zsuzsanna, Ivics, Zoltán
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464645/
https://ncbi.nlm.nih.gov/pubmed/22776959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.126
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