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A highly soluble Sleeping Beauty transposase improves control of gene insertion
The Sleeping Beauty (SB) transposon system is an efficient non-viral gene transfer tool in mammalian cells but its broad use has been hampered by uncontrolled transposase gene activity from DNA vectors, posing a risk for genome instability, and by the inability to use transposase protein directly. H...
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| Publicat a: | Nat Biotechnol |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6894935/ https://ncbi.nlm.nih.gov/pubmed/31685959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0291-z |
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