Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Somatic mutations together with immunoediting drive extensive heterogeneity within non-small-cell lung cancer (NSCLC). Herein we examine heterogeneity of the T cell antigen receptor (TCR) repertoire. The number of TCR sequences selectively expanded in tumors varies within and between tumors and corr...

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Publicado en:Nat Med
Autores principales: Joshi, Kroopa, de Massy, Marc Robert, Ismail, Mazlina, Reading, James L., Uddin, Imran, Woolston, Annemarie, Hatipoglu, Emine, Oakes, Theres, Rosenthal, Rachel, Peacock, Thomas, Ronel, Tahel, Noursadeghi, Mahdad, Turati, Virginia, Furness, Andrew J. S., Georgiou, Andrew, Wong, Yien Ning Sophia, Aissa, Assma Ben, Werner Sunderland, Mariana, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Birkbak, Nicolai J., Wilson, Gareth A., Hiley, Crispin T., Ghorani, Ehsan, Guerra-Assunção, José Afonso, Herrero, Javier, Enver, Tariq, Hadrup, Sine R., Hackshaw, Allan, Peggs, Karl S., McGranahan, Nicholas, Swanton, Charles, Quezada, Sergio A., Chain, Benny
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890490/
https://ncbi.nlm.nih.gov/pubmed/31591606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0592-2
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