The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Tumour mutational burden (TMB) predicts immunotherapy outcome in non-small cell lung cancer (NSCLC), consistent with immune recognition of tumour neoantigens. However, persistent antigen exposure is detrimental for T cell function. How TMB affects CD4 and CD8 T cell differentiation in untreated tumo...

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Pubblicato in:Nat Cancer
Autori principali: Ghorani, Ehsan, Reading, James L., Henry, Jake Y., de Massy, Marc Robert, Rosenthal, Rachel, Turati, Virginia, Joshi, Kroopa, Furness, Andrew J.S., Aissa, Assma Ben, Saini, Sunil Kumar, Ramskov, Sofie, Georgiou, Andrew, Sunderland, Mariana Werner, Wong, Yien Ning Sophia, De Mucha, Maria Vila, Day, William, Galvez-Cancino, Felipe, Becker, Pablo D., Uddin, Imran, Ismail, Mazlina, Ronel, Tahel, Woolston, Annemarie, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Birkbak, Nicolai J., Wilson, Gareth A., Litchfield, Kevin, Conde, Lucia, Guerra-Assunção, José Afonso, Blighe, Kevin, Biswas, Dhruva, Salgado, Roberto, Lund, Tom, Al Bakir, Maise, Moore, David A., Hiley, Crispin T., Loi, Sherene, Sun, Yuxin, Yuan, Yinyin, AbdulJabbar, Khalid, Turajilic, Samra, Herrero, Javier, Enver, Tariq, Hadrup, Sine R, Hackshaw, Allan, Peggs, Karl S, McGranahan, Nicholas, Chain, Benny, Swanton, Charles, Quezada, Sergio A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115931/
https://ncbi.nlm.nih.gov/pubmed/32803172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-0066-y
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