The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Tumour mutational burden (TMB) predicts immunotherapy outcome in non-small cell lung cancer (NSCLC), consistent with immune recognition of tumour neoantigens. However, persistent antigen exposure is detrimental for T cell function. How TMB affects CD4 and CD8 T cell differentiation in untreated tumo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Cancer
Main Authors: Ghorani, Ehsan, Reading, James L., Henry, Jake Y., de Massy, Marc Robert, Rosenthal, Rachel, Turati, Virginia, Joshi, Kroopa, Furness, Andrew J.S., Aissa, Assma Ben, Saini, Sunil Kumar, Ramskov, Sofie, Georgiou, Andrew, Sunderland, Mariana Werner, Wong, Yien Ning Sophia, De Mucha, Maria Vila, Day, William, Galvez-Cancino, Felipe, Becker, Pablo D., Uddin, Imran, Ismail, Mazlina, Ronel, Tahel, Woolston, Annemarie, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Birkbak, Nicolai J., Wilson, Gareth A., Litchfield, Kevin, Conde, Lucia, Guerra-Assunção, José Afonso, Blighe, Kevin, Biswas, Dhruva, Salgado, Roberto, Lund, Tom, Al Bakir, Maise, Moore, David A., Hiley, Crispin T., Loi, Sherene, Sun, Yuxin, Yuan, Yinyin, AbdulJabbar, Khalid, Turajilic, Samra, Herrero, Javier, Enver, Tariq, Hadrup, Sine R, Hackshaw, Allan, Peggs, Karl S, McGranahan, Nicholas, Chain, Benny, Swanton, Charles, Quezada, Sergio A
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115931/
https://ncbi.nlm.nih.gov/pubmed/32803172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-0066-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados