Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma

BACKGROUND: Cancer mutations generate novel (neo-)peptides recognised by T cells, but the determinants of recognition are not well characterised. The difference in predicted class I major histocompatibility complex (MHC-I) binding affinity between wild-type and corresponding mutant peptides (differe...

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Detalhes bibliográficos
Publicado no:Ann Oncol
Main Authors: Ghorani, E, Rosenthal, R, McGranahan, N, Reading, J L, Lynch, M, Peggs, K S, Swanton, C, Quezada, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Original articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834109/
https://ncbi.nlm.nih.gov/pubmed/29361136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx687
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