Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain

Molecular mechanisms that define patterns of neuropeptide expression are essential for the formation and rewiring of neural circuits. The prodynorphin gene (PDYN) gives rise to dynorphin opioid peptides mediating depression and substance dependence. We here demonstrated that PDYN is expressed in neu...

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Detalhes bibliográficos
Publicado no:Cereb Cortex
Main Authors: Bazov, Igor, Sarkisyan, Daniil, Kononenko, Olga, Watanabe, Hiroyuki, Taqi, Mumtaz Malik, Stålhandske, Lada, Verbeek, Dineke S, Mulder, Jan, Rajkowska, Grazyna, Sheedy, Donna, Kril, Jillian, Sun, Xueguang, Syvänen, Ann-Christine, Yakovleva, Tatiana, Bakalkin, Georgy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887740/
https://ncbi.nlm.nih.gov/pubmed/28968778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhx181
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