Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Molecular changes in cortical areas of addicted brain may underlie cognitive impairment and loss of control over intake of addictive substances and alcohol. Prodynorphin (PDYN) gives rise to dynorphin (DYNs) opioid peptides which target kappa-opioid receptor (KOR). DYNs mediate alcohol-induced impai...

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Pubblicato in:Transl Psychiatry
Autori principali: Bazov, Igor, Sarkisyan, Daniil, Kononenko, Olga, Watanabe, Hiroyuki, Karpyak, Victor M., Yakovleva, Tatiana, Bakalkin, Georgy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010434/
https://ncbi.nlm.nih.gov/pubmed/29925858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-017-0075-5
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