Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Molecular changes in cortical areas of addicted brain may underlie cognitive impairment and loss of control over intake of addictive substances and alcohol. Prodynorphin (PDYN) gives rise to dynorphin (DYNs) opioid peptides which target kappa-opioid receptor (KOR). DYNs mediate alcohol-induced impai...

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Publicat a:Transl Psychiatry
Autors principals: Bazov, Igor, Sarkisyan, Daniil, Kononenko, Olga, Watanabe, Hiroyuki, Karpyak, Victor M., Yakovleva, Tatiana, Bakalkin, Georgy
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010434/
https://ncbi.nlm.nih.gov/pubmed/29925858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-017-0075-5
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