Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics

Molecular changes induced by excessive alcohol consumption may underlie formation of dysphoric state during acute and protracted alcohol withdrawal which leads to craving and relapse. A main molecular addiction hypothesis is that the upregulation of the dynorphin (DYN)/κ-opioid receptor (KOR) system...

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Publicado en:Mol Neurobiol
Main Authors: Bazov, Igor, Sarkisyan, Daniil, Kononenko, Olga, Watanabe, Hiroyuki, Yakovleva, Tatiana, Hansson, Anita C., Sommer, Wolfgang H., Spanagel, Rainer, Bakalkin, Georgy
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061161/
https://ncbi.nlm.nih.gov/pubmed/29383684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-017-0844-4
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