Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Molecular changes in cortical areas of addicted brain may underlie cognitive impairment and loss of control over intake of addictive substances and alcohol. Prodynorphin (PDYN) gives rise to dynorphin (DYNs) opioid peptides which target kappa-opioid receptor (KOR). DYNs mediate alcohol-induced impai...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Transl Psychiatry
Egile Nagusiak: Bazov, Igor, Sarkisyan, Daniil, Kononenko, Olga, Watanabe, Hiroyuki, Karpyak, Victor M., Yakovleva, Tatiana, Bakalkin, Georgy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010434/
https://ncbi.nlm.nih.gov/pubmed/29925858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-017-0075-5
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