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Copper Inhibits the AlkB Family DNA Repair Enzymes under Wilson’s Disease Condition

Disturbed metabolism of copper ions can cause diseases such as Wilson’s disease (WD). In this work, we investigated the inhibitory effect of Cu(II) ion in vitro on the AlkB family DNA repair enzymes, which are members of the Fe(II)/alpha-ketoglutarate-dependent dioxygenase and include human ALKBH2,...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Bian, Ke, Chen, Fangyi, Humulock, Zachary T., Tang, Qi, Li, Deyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885016/
https://ncbi.nlm.nih.gov/pubmed/28926697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00230
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