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Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage
The AlkB repair enzymes, including Escherichia coli AlkB and two human homologues, ALKBH2 and ALKBH3, are iron(II)- and 2-oxoglutarate-dependent dioxygenases that efficiently repair N(1)-methyladenine and N(3)-methylcytosine methylated DNA damages. The development of small molecule inhibitors of the...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4900258/ https://ncbi.nlm.nih.gov/pubmed/27015802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.711895 |
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