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Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB
AlkB is a bacterial Fe(II)– and 2-oxoglutarate–dependent dioxygenase that repairs a wide range of alkylated nucleobases in DNA and RNA as part of the adaptive response to exogenous nucleic acid–alkylating agents. Although there has been longstanding interest in the structure and specificity of Esche...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7247310/ https://ncbi.nlm.nih.gov/pubmed/32284330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013517 |
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