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Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB

AlkB is a bacterial Fe(II)– and 2-oxoglutarate–dependent dioxygenase that repairs a wide range of alkylated nucleobases in DNA and RNA as part of the adaptive response to exogenous nucleic acid–alkylating agents. Although there has been longstanding interest in the structure and specificity of Esche...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Baldwin, Michael R., Admiraal, Suzanne J., O'Brien, Patrick J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247310/
https://ncbi.nlm.nih.gov/pubmed/32284330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013517
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