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Dynamic states of the DNA repair enzyme AlkB regulate product release

The 2-oxoglutarate (2OG)- and Fe(2+)-dependent dioxygenase AlkB couples the demethylation of modified DNA to the decarboxylation of 2OG. Extensive crystallographic analyses have shown no evidence of significant structural differences between complexes binding either 2OG or succinate. By using nuclea...

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Detalhes bibliográficos
Main Authors: Bleijlevens, Boris, Shivarattan, Tara, Flashman, Emily, Yang, Yi, Simpson, Pete J, Koivisto, Pertti, Sedgwick, Barbara, Schofield, Christopher J, Matthews, Steve J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529343/
https://ncbi.nlm.nih.gov/pubmed/18617893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.120
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