Dynamic states of the DNA repair enzyme AlkB regulate product release

The 2-oxoglutarate (2OG)- and Fe(2+)-dependent dioxygenase AlkB couples the demethylation of modified DNA to the decarboxylation of 2OG. Extensive crystallographic analyses have shown no evidence of significant structural differences between complexes binding either 2OG or succinate. By using nuclea...

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Main Authors: Bleijlevens, Boris, Shivarattan, Tara, Flashman, Emily, Yang, Yi, Simpson, Pete J, Koivisto, Pertti, Sedgwick, Barbara, Schofield, Christopher J, Matthews, Steve J
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2008
主題:
Scientific Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529343/
https://ncbi.nlm.nih.gov/pubmed/18617893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.120
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