Loading...
Oncometabolites D- and L-2-hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions
Cancer-associated mutations often lead to perturbed cellular energy metabolism and accumulation of potentially harmful oncometabolites. One example is the chiral molecule 2-hydroxyglutarate (2HG); its two stereoisomers (D- and L-2HG) have been found with abnormally high concentrations in tumors feat...
Na minha lista:
| Udgivet i: | Chem Res Toxicol |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5498157/ https://ncbi.nlm.nih.gov/pubmed/28269980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00009 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|