Characterization of six recombinant human RNase H2 bearing Aicardi-Goutiéres syndrome causing mutations

Mammalian RNase H2 is a heterotrimeric enzyme consisting of one catalytic subunit (A) and two accessory subunits (B and C). RNase H2 is involved in the removal of a single ribonucleotide embedded in genomic DNA and removal of RNA of RNA/DNA hybrids. In humans, mutation of the RNase H2 gene causes a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biochem
Hauptverfasser: Nishimura, Takuto, Baba, Misato, Ogawa, Saori, Kojima, Kenji, Takita, Teisuke, Crouch, Robert J, Yasukawa, Kiyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Regular Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882408/
https://ncbi.nlm.nih.gov/pubmed/31529068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvz073
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