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Genome Instability Consequences of RNase H2 Aicardi-Goutières Syndrome Alleles
The RNase H2 complex is a conserved heterotrimeric enzyme that degrades RNA:DNA hybrids and promotes excision of rNMPs misincorporated during DNA replication. Failure to remove ribonucleotides from DNA leads to genomic instability in yeast and humans. The monogenic Aicardi-Goutières syndrome (AGS) r...
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| Publicado no: | DNA Repair (Amst) |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6495547/ https://ncbi.nlm.nih.gov/pubmed/30975634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.04.002 |
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