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Reduction of hRNase H2 activity in Aicardi–Goutières syndrome cells leads to replication stress and genome instability
Aicardi–Goutières syndrome (AGS) is an inflammatory encephalopathy caused by defective nucleic acids metabolism. Over 50% of AGS mutations affect RNase H2 the only enzyme able to remove single ribonucleotidemonophosphates (rNMPs) embedded in DNA. Ribonucleotide triphosphates (rNTPs) are incorporated...
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| 出版年: | Hum Mol Genet |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291245/ https://ncbi.nlm.nih.gov/pubmed/25274781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu485 |
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