Učitavanje...
Reduction of hRNase H2 activity in Aicardi–Goutières syndrome cells leads to replication stress and genome instability
Aicardi–Goutières syndrome (AGS) is an inflammatory encephalopathy caused by defective nucleic acids metabolism. Over 50% of AGS mutations affect RNase H2 the only enzyme able to remove single ribonucleotidemonophosphates (rNMPs) embedded in DNA. Ribonucleotide triphosphates (rNTPs) are incorporated...
Spremljeno u:
| Izdano u: | Hum Mol Genet |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2015
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291245/ https://ncbi.nlm.nih.gov/pubmed/25274781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu485 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|