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RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases
Mutations in the genes encoding the RNaseH2 and TREX1 nucleases have been identified in patients with Aicardi-Goutieres syndrome (AGS). To determine if the AGS RNaseH2 mutations result in the loss of nuclease activity, the human wild-type RNaseH2 and four mutant complexes that constitute the majorit...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2852111/ https://ncbi.nlm.nih.gov/pubmed/19034401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-008-0422-3 |
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