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Functional Consequences of the RNase H2A Subunit Mutations That Cause Aicardi-Goutières Syndrome
Mutations in the three genes encoding the heterotrimeric RNase H2 complex cause Aicardi-Goutières Syndrome (AGS). Our mouse RNase H2 structure revealed that the catalytic RNase H2A subunit interfaces mostly with the RNase H2C subunit that is intricately interwoven with the RNase H2B subunit. We mapp...
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| Main Authors: | , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Biochemistry and Molecular Biology
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3089542/ https://ncbi.nlm.nih.gov/pubmed/21454563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228833 |
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