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Genome Instability Consequences of RNase H2 Aicardi-Goutières Syndrome Alleles

The RNase H2 complex is a conserved heterotrimeric enzyme that degrades RNA:DNA hybrids and promotes excision of rNMPs misincorporated during DNA replication. Failure to remove ribonucleotides from DNA leads to genomic instability in yeast and humans. The monogenic Aicardi-Goutières syndrome (AGS) r...

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Bibliografski detalji
Izdano u:DNA Repair (Amst)
Glavni autori: Potenski, Catherine J, Epshtein, Anastasiya, Bianco, Christopher, Klein, Hannah L.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495547/
https://ncbi.nlm.nih.gov/pubmed/30975634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.04.002
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