Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity

Ribonuclease H2 (RNase H2) exhibits both single ribonucleotide excision activity (activity A) and RNA strand degrading activity (activity B). Val143 of human RNase H2 is located at the active site and is conserved in eukaryotic RNase H2. In this study, we explored the role of Val143 in catalytic act...

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Publicado en:PLoS One
Autores principales: Baba, Misato, Kojima, Kenji, Nishimura, Takuto, Sugiura, Takuya, Takita, Teisuke, Uehara, Ryo, Crouch, Robert J., Yasukawa, Kiyoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028304/
https://ncbi.nlm.nih.gov/pubmed/32069311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228774
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