Human CD8(+) Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice

Polyclonal CD8(+)CD45RC(low/−) Tregs are potent regulatory cells able to control solid organ transplantation rejection and even induce tolerance. However, donor major histocompatibility complex (MHC)–specific Tregs are more potent than polyclonal Tregs in suppressing T-cell responses and preventing...

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Vydáno v:Blood Adv
Hlavní autoři: Bézie, Séverine, Charreau, Béatrice, Vimond, Nadège, Lasselin, Juliette, Gérard, Nathalie, Nerrière-Daguin, Véronique, Bellier-Waast, Frédérique, Duteille, Franck, Anegon, Ignacio, Guillonneau, Carole
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Immunobiology and Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880915/
https://ncbi.nlm.nih.gov/pubmed/31730699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000411
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