Ex Vivo Expanded Human Non-Cytotoxic CD8(+)CD45RC(low/−) Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice

Both CD4(+) and CD8(+) Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8(+) Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8(+)CD45RC(low/−)...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bézie, Séverine, Meistermann, Dimitri, Boucault, Laetitia, Kilens, Stéphanie, Zoppi, Johanna, Autrusseau, Elodie, Donnart, Audrey, Nerrière-Daguin, Véronique, Bellier-Waast, Frédérique, Charpentier, Eric, Duteille, Franck, David, Laurent, Anegon, Ignacio, Guillonneau, Carole
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797797/
https://ncbi.nlm.nih.gov/pubmed/29445370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.02014
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