Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells

Rat and human CD4(+) and CD8(+) Tregs expressing low levels of CD45RC have strong immunoregulatory properties. We describe here that human CD45 isoforms are nonredundant and identify distinct subsets of cells. We show that CD45RC is not expressed by CD4(+) and CD8(+) Foxp3(+) Tregs, while CD45RA/RB/...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Picarda, Elodie, Bézie, Séverine, Boucault, Laetitia, Autrusseau, Elodie, Kilens, Stéphanie, Meistermann, Dimitri, Martinet, Bernard, Daguin, Véronique, Donnart, Audrey, Charpentier, Eric, David, Laurent, Anegon, Ignacio, Guillonneau, Carole
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291739/
https://ncbi.nlm.nih.gov/pubmed/28194440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90088
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