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Human CD8(+) Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice
Polyclonal CD8(+)CD45RC(low/−) Tregs are potent regulatory cells able to control solid organ transplantation rejection and even induce tolerance. However, donor major histocompatibility complex (MHC)–specific Tregs are more potent than polyclonal Tregs in suppressing T-cell responses and preventing...
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| 出版年: | Blood Adv |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6880915/ https://ncbi.nlm.nih.gov/pubmed/31730699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000411 |
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