Human CD8(+) Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice

Polyclonal CD8(+)CD45RC(low/−) Tregs are potent regulatory cells able to control solid organ transplantation rejection and even induce tolerance. However, donor major histocompatibility complex (MHC)–specific Tregs are more potent than polyclonal Tregs in suppressing T-cell responses and preventing...

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Guardat en:
Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Bézie, Séverine, Charreau, Béatrice, Vimond, Nadège, Lasselin, Juliette, Gérard, Nathalie, Nerrière-Daguin, Véronique, Bellier-Waast, Frédérique, Duteille, Franck, Anegon, Ignacio, Guillonneau, Carole
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Immunobiology and Immunotherapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880915/
https://ncbi.nlm.nih.gov/pubmed/31730699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000411
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