Human CD8(+) Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice

Polyclonal CD8(+)CD45RC(low/−) Tregs are potent regulatory cells able to control solid organ transplantation rejection and even induce tolerance. However, donor major histocompatibility complex (MHC)–specific Tregs are more potent than polyclonal Tregs in suppressing T-cell responses and preventing...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Bézie, Séverine, Charreau, Béatrice, Vimond, Nadège, Lasselin, Juliette, Gérard, Nathalie, Nerrière-Daguin, Véronique, Bellier-Waast, Frédérique, Duteille, Franck, Anegon, Ignacio, Guillonneau, Carole
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880915/
https://ncbi.nlm.nih.gov/pubmed/31730699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000411
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