Human CD8(+) Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice

Polyclonal CD8(+)CD45RC(low/−) Tregs are potent regulatory cells able to control solid organ transplantation rejection and even induce tolerance. However, donor major histocompatibility complex (MHC)–specific Tregs are more potent than polyclonal Tregs in suppressing T-cell responses and preventing...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Bézie, Séverine, Charreau, Béatrice, Vimond, Nadège, Lasselin, Juliette, Gérard, Nathalie, Nerrière-Daguin, Véronique, Bellier-Waast, Frédérique, Duteille, Franck, Anegon, Ignacio, Guillonneau, Carole
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2019
Soggetti:
Immunobiology and Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880915/
https://ncbi.nlm.nih.gov/pubmed/31730699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000411
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